Medical Collagen Membrane

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• Category : Medical devices/General Surgery Devices
• Description :
• Periodontal diseases that lead to the destruction of periodontal tissues-including periodontal ligament(PDL), cementum, and bone are a major cause of tooth loss in adults and are a substantial public-health burden worldwide. To regenerate periodontal tissue and reserve tooth is always a highlight for many researchers, many new approaches have been developed for treating periodontal defects, including guided tissue regeneration, growth factors, and enamel matrix proteins, and tissue engineering offers a new option to supplement existing treatment regimen for periodontal tissue regeneration. Tissue engineering is a newly emerging biomedical technique that involves the artificial manipulation of cells to promote tissue and organ regeneration. This can be seen as the third medical therapy in regenerative medicine following the two major clinical therapies, organ transplantation and reconstructive surgery in the 21st century. The object of tissue engineering is to regenerate natural tissues from living cells to replace defective or lost tissues and organs. Tissue or organ regeneration using tissue engineering methods will require integration of three key elements: Inductive morphogenetic signal, responding progenitor/stem cells and the extracellular matrix scaffold. Moreover, to induce morphogenesis of periodontum, these elements must be combined to facilitate a developmental cascade of pattern formation. Compared with other parts of the body, the oral cavity offers distinct advantages to the tissue engineering, such as ease of observation and accessibility. In recent years, many adult stem cells have been identified and successfully isolated from various tissues including bone marrow, muscle, neurtal tissue, skin, dental pulp and so on. One discovery suggests that PDL contains stem cells that have the potential to generate cementum/PDL-like tissue in vivo. It has been that human periodontal ligament stem cell (PDLSCs) could repair periodontal destroy of nude mice. PDLSCs are similar to other adult stem cells so far have been identified and they have great potential of self-replication and can diffentiate into functional mature cell types or trans-differentiate into other cell types. Though successful isolation of human PDLSCs has been reported, investigations on dog PDLSCs and studies on tissue engineering of periodontal-like structures by cultured dog PDLSCs have not yet been documented. As one of the most frequently used animal models in periodontal disease scitientific research, dog also play an important role in periodontal disease because it's less costly and high homogeneity in comparison with human beings. In this study, dog PDLSCs clones were isolated from cultured periodontal ligament cells(PDLCs) and the isolated clones were characterized through series of biological examinations, and were implanted to artificial furcation defects combined with ceramic bovine bone (CBB) to regenerate dog allograf periodontal defects. Dental follicle, which has been implicated as the origion of alvelar bone, cementum and periodontal ligament, is the fibrous tissue that surrounds the developing tooth germ, and it is believed to contain progenitors for cementoblasts, periodontal ligament cells, and osteoblasts. With the advance of study of periodontal tissue engineer, some scientists have attemped to get periodontum using dental follicle cells as seeded cells. In this study, human dental follicle cells(DFCs) were isolated and charaterized, and were implanted into scoffalds to select periodontal tissue engineering scoffalds. We isolated dog PDLSCs from adult dog teeth and human DFCs from tooth germ tissue at late development, and select suitable scoffalds for periodontal tissue engineering, and PDLSCs was induced to differentiate into cementoblasts/osteoblasts for periodontal tissue engineering. Medical collagen membrane Company: Nature's Best Biotech Co., Ltd.